Analysis of Myelomonocytic Leukemic Differentiation by a Cell Surface Marker Panel Including a Fucose - Binding Lectin
نویسنده
چکیده
The fucose-binding lectin from Lotus tetragonolobus (FBII) has been previously shown to bind specifically to normal cells of the myeloid and monocytic lineages. The purpose of this study was to explore the utility of fluoresceinated FBI-I as a leukemia differentiation marker in conjunction with a panel of other frequently used surface markers (Fe receptor. HIA-DR. OKM1 . and antimonocyte antibody). FBI-I reacted with leukemic cells in 8/9 cases of clinically recognized acute myeloid leukemia. including myeloid blast crisis of chronic granubocytic leukemia. 3/3 cases of chronic phase chronic myelogenous leukemia. and in 2/7 cases of clinically undifferentiated acute leukemia. Correlations were noted between reactivity with FBI-I. and DR and Fc receptor expression. Among continuous cell lines. FBI-I bound with high intensity to a majority of HI-60 and
منابع مشابه
Analysis of myelomonocytic leukemic differentiation by a cell surface marker panel including a fucose-binding lectin from Lotus tetragonolobus.
The fucose-binding lectin from Lotus tetragonolobus ( FBL -L) has been previously shown to bind specifically to normal cells of the myeloid and monocytic lineages. The purpose of this study was to explore the utility of fluoresceinated FBL -L as a leukemia differentiation marker in conjunction with a panel of other frequently used surface markers (Fc receptor, HLA-DR, OKM1, and antimonocyte ant...
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